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Gene delivery from replication-selective viruses: arming guided missiles in the war against cancer

1 May 2000

Abstract excerpt

Gene therapy aims to deliver therapeutic genetic material in a safe and efficient manner to a target tissue, where it can accumulate to levels that afford maximal patient benefit. Replication-defective viral vectors have been the workhorse of gene therapy for cancer and other conditions. These vectors allow the efficient delivery of a variety of transgenes to target tissues and have demonstrated clear therapeutic...

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PMID: 10791988
DOI: 10.1172/jci9973

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