Loss of nucleobindin-2 causes nigrastriatal degeneration in mice by impacting circadian rhythm-related genes and gut microbiota

Abstract excerpt

<title>Abstract</title> <p> Nesfatin-1 is a brain-gut peptide encoded by the nucleobindin-2 (NUCB2) gene. We previously demonstrated that a reduced level of nesfatin-1 in the cerebrospinal fluid, induced by intracerebroventricular injection of a nesfatin-1 antibody, is associated with degeneration of the nigrostriatal dopaminergic system. In combination with evidence that nesfatin-1 mediated the rescue of toxica...

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• Amyotrophic Lateral Sclerosis
• Digestive System
• Dysbiosis
• Enteric Nervous System
• Gastrointestinal Microbiome
• Huntington Disease
• Models, Neurological
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

b8cde136-7715-5daa-bb7b-5a192fa7b2fc

DOI

10.21203/rs.3.rs-7332954/v1