Article

Parkin coordinates mitochondrial lipid remodeling to execute mitophagy

2020-02-28

Abstract excerpt

Mitochondrial failure caused by Parkin mutations contributes to Parkinson’s disease. Parkin binds, ubiquitinates, and targets impaired mitochondria for autophagic destruction. Robust mitophagy involves peri-nuclear concentration of Parkin-tagged mitochondria, followed by dissemination of juxtanuclear mitochondrial aggregates, and efficient sequestration of individualized mitochondria by autophagosomes. Here, we re...

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Identifiers and source

Literature Corpus work: bb108092-2526-5848-a5ee-07dbb324b26a
DOI: 10.1101/2020.02.28.970210

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