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Article

Unconventional initiation of PINK1/Parkin mitophagy by Optineurin

1 May 2023

Abstract excerpt

Cargo sequestration is a fundamental step of selective autophagy in which cells generate a double-membrane structure termed an "autophagosome" on the surface of cargoes. NDP52, TAX1BP1, and p62 bind FIP200, which recruits the ULK1/2 complex to initiate autophagosome formation on cargoes. How OPTN initiates autophagosome formation during selective autophagy remains unknown despite its importance in...

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Identifiers

PMID: 37207627
DOI: 10.1016/j.molcel.2023.04.021

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