Article

Molecular Control of Non-Muscle Myosin II-A Aggregation and Intracellular Dynamics by motor- or tail-specific <i>MYH9</i> Mutations

2025-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the MYH9 gene, which encodes the actin-based molecular motor non-muscle myosin II-A (NM2-A), cause a group of blood disorders termed MYH9 -related diseases ( MYH9 -RD). While correlation between genotype and phenotype is not well characterized at a molecular level, motor mutations seem to cause more severe phenotypes than tail mutations. Motor domain mutation N93K, previously des...

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Literature Corpus work: bb024fc5-a450-5dd3-b7e5-da6199e2c880
DOI: 10.1101/2025.05.20.654665

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