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Article

MYH9 mutations differentially stabilize non-muscle myosin II filaments and induce distinct cellular aggregation phenotypes.

Cellular and molecular life sciences : CMLS - 28 Feb 2026

Llorente-González Clara, Mustafina Kamila, Asensio-Juárez Gloria, Garrido-Casado Marina, Talayero Vanessa C, Pérez-Díaz Rafael, Ramos-Solano Hugo, Sellers James R, Chinthalapudi Krishna, Wiseman Paul W, Heissler Sarah M, Vicente-Manzanares Miguel

Abstract excerpt

Mutations in the MYH9 gene, which encodes the heavy chain of the actin-based molecular motor non-muscle myosin II-A (NM2-A), cause a spectrum of rare blood disorders collectively termed MYH9-related diseases (MYH9-RD). Previous data indicate that mutations in the motor domain result in more severe phenotypes than those in the dimerization/filamentation domain. Here, we show that N93K mutation, previously...

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Identifiers

PMID: 41760963
DOI: 10.1007/s00018-026-06119-y
PMCID: PMC12961093

Genes

MYH9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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MYH9 mutations differentially stabilize non-muscle myosin II filaments and induce distinct cellular aggregation phenotypes.PMID 41760963Read ↗

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