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Article

MYH-9 Related Platelet Disorders: Strategies for Management and Diagnosis

1 Jan 2010

Abstract excerpt

MYH-9 related platelet disorders belong to the group of inherited giant platelet disorders. The MYH-9 gene encodes the non-muscular myosin heavy chain IIA (NMMHCIIA), a cytoskeletal contractile protein. Several mutations in the MYH-9 gene lead to macrothrombocytopenia, and cytoplasmic inclusion bodies within leukocytes, while the number of megakaryocytes in the bone marrow is normal. Four overlapping syndromes,...

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PMID: 21113248
DOI: 10.1159/000320335

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