Article

Loss of recognition of SARS-CoV-2 B.1.351 variant spike epitopes but overall preservation of T cell immunity

2021-06-06

Abstract excerpt

SARS-CoV-2 variants have emerged that escape neutralization and potentially impact vaccine efficacy. T cell responses play a role in protection from reinfection and severe disease, but the potential for spike mutations to affect T cell immunity is poorly studied. We assessed both neutralizing antibody and T cell responses in 44 South African COVID-19 patients infected either with B.1.351, now dominant in South Afr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: baff2150-aa3b-5ace-af97-30809009853a
DOI: 10.1101/2021.06.03.21258307

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of recognition of SARS-CoV-2 B.1.351 variant spike epitopes but overall preservation of T cell immunityDOI 10.1101/2021.06.03.21258307Read

Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunitySemantic proximity Read

Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccinationSemantic proximity Read

Serum Neutralizing Activity against B.1.1.7, B.1.351, and P.1 SARS-CoV-2 Variants of Concern in Hospitalized COVID-19 Patients.Semantic proximity Read

Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccinationSemantic proximity Read

SARS-CoV-2 immune evasion by variant B.1.427/B.1.429Semantic proximity Read

SARS-CoV-2 spike T cell responses induced upon vaccination or infection remain robust against OmicronSemantic proximity Read

Mutations in spike protein T cell epitopes of SARS-COV-2 variants: Plausible influence on vaccine efficacy.Semantic proximity Read

SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines.Semantic proximity Read

Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7.Semantic proximity Read

SARS-CoV-2 B.1.1.7 escape from mRNA vaccine-elicited neutralizing antibodiesSemantic proximity Read

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variantsSemantic proximity Read

New SARS-CoV-2 lineages could evade CD8+ T-cells responseSemantic proximity Read