Article

Structural basis for the ligand promiscuity of the neofunctionalized, carotenoid-binding fasciclin domain protein AstaP

2022-12-26

Abstract excerpt

<h4>ABSTRACT</h4> Fasciclins (FAS1) are ancient adhesion protein domains found across different phyla from bacteria to humans, with no common small ligand binding function reported. A unique FAS1-containing astaxanthin-binding protein (AstaP) from green algae can efficiently bind an unusually broad repertoire of carotenoids (astaxanthin, zeaxanthin, canthaxanthin, β-carotene), but the underlying mechanism is larg...

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Literature Corpus work: bafc0134-0427-5da6-936b-bd75b1bfc868
DOI: 10.1101/2022.12.26.521925

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