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Article

mTOR-dependent translation drives tumor infiltrating CD8+ effector and CD4+ Treg cells expansion

8 Nov 2021

Abstract excerpt

We performed a systematic analysis of the translation rate of tumor-infiltrating lymphocytes (TILs) and the microenvironment inputs affecting it, both in humans and in mice. Measurement of puromycin incorporation, a proxy of protein synthesis, revealed an increase of translating CD4 + and CD8 + cells in tumors, compared to normal tissues. High translation levels are associated with phospho-S6 labeling downstream...

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PMID: 34787568
DOI: 10.7554/elife.69015

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