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Comparative Analysis of Genetic Variations in the Nav1.5 Sodium Channel Subunits that Underlie Brugada Syndrome Using Patient-Specific iPSC-CMs

2020-09-03

Abstract excerpt

<h4>Background: </h4> Brugada syndrome (BrS) is an autosomal dominant disorder that causes a high predisposition to sudden cardiac death. Several genes have been reported to be associated with BrS. Considering that the heterogeneity in clinical manifestations may result from genetic variations, the application of patient-specific induced pluripotent stem (iPS) cell-derived cardiomyocytes (CMs) may help to reveal c...

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Literature Corpus work
badd9e86-d2d2-5928-973c-b2afd635a84c
DOI
10.21203/rs.3.rs-70177/v1
Open publication

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Comparative Analysis of Genetic Variations in the Nav1.5 Sodium Channel Subunits that Underlie Brugada Syndrome Using Patient-Specific iPSC-CMsDOI 10.21203/rs.3.rs-70177/v1
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