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Article

Studying Brugada Syndrome With an SCN1B Variants in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

1 Nov 2019

Abstract excerpt

Background Among rare channelopathies BrS patients are at high risk of sudden cardiac death (SCD). SCN5A mutations are found in a quarter of patients. Other rare gene mutations including SCN1B have been implicated to BrS. Studying the human cellular phenotype of BrS associated with rare gene mutation remains lacking. Objectives We sought to study the cellular phenotype of BrS with the SCN1B gene mutations using...

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Identifiers

PMID: 31737628
DOI: 10.3389/fcell.2019.00261

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