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Article

Patient-specific iPSC-derived cardiomyocytes reveal variable phenotypic severity of Brugada syndrome.

EBioMedicine - 1 Sept 2023

Sun Yaxun, Su Jun, Wang Xiaochen, Wang Jue, Guo Fengfeng, Qiu Hangyuan, Fan Hangping, Cai Dongsheng, Wang Hao, Lin Miao, Wang Wei, Feng Ye, Fu Guosheng, Gong Tingyu, Liang Ping, Jiang Chenyang

Abstract excerpt

BACKGROUND: Brugada syndrome (BrS) is a cardiac channelopathy that can result in sudden cardiac death (SCD). SCN5A is the most frequent gene linked to BrS, but the genotype-phenotype correlations are not completely matched. Clinical phenotypes of a particular SCN5A variant may range from asymptomatic to SCD. Here, we used comparison of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) derived from a...

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Identifiers

PMID: 37544203
DOI: 10.1016/j.ebiom.2023.104741
PMCID: PMC10427992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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