Article
Patient-Specific and Genome-Edited Induced Pluripotent Stem Cell-Derived Cardiomyocytes Elucidate Single-Cell Phenotype of Brugada Syndrome.
Journal of the American College of Cardiology - 8 Nov 2016
Liang Ping, Sallam Karim, Wu Haodi, Li Yingxin, Itzhaki Ilanit, Garg Priyanka, Zhang Ying, Vermglinchan Vittavat, Lan Feng, Gu Mingxia, Gong Tingyu, Zhuge Yan, He Chunjiang, Ebert Antje D, Sanchez-Freire Veronica, Churko Jared, Hu Shijun, Sharma Arun, Lam Chi Keung, Scheinman Melvin M, Bers Donald M, Wu Joseph C
Abstract excerpt
BACKGROUND: Brugada syndrome (BrS), a disorder associated with characteristic electrocardiogram precordial ST-segment elevation, predisposes afflicted patients to ventricular fibrillation and sudden cardiac death. Despite marked achievements in outlining the organ level pathophysiology of the disorder, the understanding of human cellular phenotype has lagged due to a lack of adequate human cellular models of the...
Topics
- Adolescent
- Adult
- Brugada Syndrome
- Cell Differentiation
- Electrocardiography
- Gene Expression Regulation
- Genotype
- Heart Conduction System