Article

Context-dependent response of endothelial cells to <i>PIK3CA</i> mutation

2025-02-25

Abstract excerpt

Cancer mutations in the PIK3CA gene cause congenital disorders. The endothelium is among the most frequently affected tissues in these disorders, displaying aberrant vascular overgrowth in the form of malformations. Pathological PIK3CA vascular phenotypes are found in veins and capillaries but rarely in arteries for reasons that are unclear at present. Here, using lineage tracing, we show that expression of muta...

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Identifiers and source

Literature Corpus work: baca8130-f698-586c-ba5f-55d6c6d311cb
DOI: 10.1101/2025.02.25.640041

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