Article

Patient-specific functional genomics and disease modeling suggest a role for LRP2 in hypoplastic left heart syndrome

2019-11-09

Abstract excerpt

<h4>ABSTRACT</h4> Congenital heart diseases (CHD), such as hypoplastic left heart syndrome (HLHS), are considered to have complex genetic underpinnings that are poorly understood. Here, an integrated multi-disciplinary approach was applied to identify novel genes and underlying mechanisms associated with HLHS. A family-based strategy was employed that coupled whole genome sequencing (WGS) with RNA sequencing of p...

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Literature Corpus work: bac03416-8c84-59cd-9d51-3c833b4d3621
DOI: 10.1101/835439

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