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Article

Contribution of LRP1 in Human Congenital Heart Disease Correlates with Its Roles in the Outflow Tract and Atrioventricular Cushion Development.

Genes - 21 Apr 2023

Arrigo Angelo B, Zhu Wenjuan, Williams Kylia A, Guzman-Moreno Carla, Lo Cecilia, Lin Jiuann-Huey I

Abstract excerpt

Due to the prevalence of congenital heart disease in the human population, determining the role of variants in congenital heart disease (CHD) can give a better understanding of the cause of the disorder. A homozygous missense mutation in the LDL receptor-related protein 1 (Lrp1) in mice was shown to cause congenital heart defects, including atrioventricular septal defect (AVSD) and double outlet right ventricle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37107705
DOI: 10.3390/genes14040947
PMCID: PMC10137934

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