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Vitamin D modulates cortical transcriptome and behavioral phenotypes in an Mecp2 heterozygous Rett syndrome mouse model

2021-07-01

Abstract excerpt

Rett syndrome (RTT) is an X-linked neurological disorder caused by mutations in the transcriptional regulator MECP2 . Mecp2 loss-of-function leads to the disruption of many cellular pathways, including aberrant activation of the NF-κB pathway. Genetically attenuating the NF-κB pathway in Mecp2 -null mice ameliorates hallmark phenotypes of RTT, including reduced dendritic complexity, raising the question of whet...

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Literature Corpus work: 8c331983-e206-5670-b01e-6a2171460fe6
DOI: 10.1101/2021.06.30.450587

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Vitamin D modulates cortical transcriptome and behavioral phenotypes in an <i>Mecp2</i> heterozygous Rett syndrome mouse model

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