Article

Acquired Cross-resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of <i>MYC</i> paralogs

2023-06-26

Abstract excerpt

<h4>ABSTRACT</h4> Small cell lung cancer (SCLC) presents as a highly chemosensitive malignancy but acquires cross-resistance after relapse. This transformation is nearly inevitable in patients but has been difficult to capture in laboratory models. Here we present a pre-clinical system that recapitulates acquired cross-resistance in SCLC, developed from 51 patient-derived xenografts (PDXs). Each model was tested...

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Literature Corpus work: bab16716-cf81-53eb-b074-79e0ba9b7f6e
DOI: 10.1101/2023.06.23.546278

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