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Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer

13 May 2022

Abstract excerpt

In small cell lung cancer (SCLC), acquired resistance to DNA-damaging therapy is challenging to study because rebiopsy is rarely performed. We used patient-derived xenograft models, established before therapy and after progression, to dissect acquired resistance to olaparib plus temozolomide (OT), a promising experimental therapy for relapsed SCLC. These pairs of serial models reveal alterations in both cell...

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PMID: 35559669
DOI: 10.1126/sciadv.abn1229

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