Article

Time-resolved inference of gene regulatory networks underlying human cranial neural crest development suggests novel risk genes for orofacial clefting

2026-06-30

Abstract excerpt

Cranial neural crest cells (CNCCs) play a central role in shaping the human head and face. Aberrant CNCC differentiation contributes to craniofacial birth defects, particularly non-syndromic cleft lip with or without cleft palate (nsCL/P), one of the most common congenital disorders. Although the number of genetic variants associated with this condition is steadily increasing, it remains challenging to determine i...

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Literature Corpus work: 70285ce6-b496-517f-92da-c340277ecb80
DOI: 10.64898/2026.06.25.734423

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