Article

Evaluating the utility of amino acid similarity-aware kmers to represent TCR repertoires for classification

2024-12-10

Abstract excerpt

Insights gained through interpretation of models trained on the T-cell receptor (TCR) repertoire contribute to advances in understanding of immune-mediated disease. This has the potential to improve diagnostic tests and treatments, particularly for autoimmune diseases. However, TCR repertoire datasets with samples from donors of known autoimmune disease status generally include orders of magnitude fewer samples th...

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Literature Corpus work: ba5c4f7c-45d0-5951-86ef-da257ffeaba5
DOI: 10.1101/2024.12.06.626025

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