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Article

A global brain state underlies C. elegans sleep behavior.

Science (New York, N.Y.) - 23 Jun 2017

Nichols Annika L A, Eichler Tomáš, Latham Richard, Zimmer Manuel

Abstract excerpt

How the brain effectively switches between and maintains global states, such as sleep and wakefulness, is not yet understood. We used brainwide functional imaging at single-cell resolution to show that during the developmental stage of lethargus, the Caenorhabditis elegans brain is predisposed to global quiescence, characterized by systemic down-regulation of neuronal activity. Only a few specific neurons are...

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PMID: 28642382
DOI: 10.1126/science.aam6851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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