Article
The spatial phenotype of genotypically distinct meningiomas demonstrate potential implications of the embryology of the meninges.
Oncogene - 1 Feb 2021
Fountain Daniel M, Smith Miriam J, O'Leary Claire, Pathmanaban Omar N, Roncaroli Federico, Bobola Nicoletta, King Andrew T, Evans Dafydd Gareth
Abstract excerpt
Meningiomas are the most common primary brain tumor and their incidence and prevalence is increasing. This review summarizes current evidence regarding the embryogenesis of the human meninges in the context of meningioma pathogenesis and anatomical distribution. Though not mutually exclusive, chromosomal instability and pathogenic variants affecting the long arm of chromosome 22 (22q) result in meningiomas in...
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