Article

Population pharmacokinetic model to generate mechanistic insights in bile acid homeostasis and drug-induced cholestasis

2024-01-31

Abstract excerpt

<h4>Background: </h4> and Purpose – Bile acids (BA) fulfill a wide range of physiological functions, but are also involved in pathologies, such as cholestasis. Cholestasis is characterized by an intrahepatic accumulation of BAs and subsequent spillage to the systemic circulation. The aim of the present study was to develop a physiologically based pharmacokinetic (PBPK) model, that would provide a tool to predict d...

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Literature Corpus work: ba245ff1-341a-5f80-b5c9-d8de81e75b51
DOI: 10.22541/au.170668617.76387369/v1

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