Article

Learning chemical sensitivity reveals mechanisms of cellular response

2023-08-28

Abstract excerpt

Chemical probes interrogate disease mechanisms at the molecular level by linking genetic changes to observable traits. However, comprehensive chemical screens in diverse biological models are impractical. To address this challenge, we developed ChemProbe, a model that predicts cellular sensitivity to hundreds of molecular probes and drugs by learning to combine transcriptomes and chemical structures. Using ChemPro...

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Literature Corpus work: b9def933-e92f-5c44-bef3-eff0cb85639d
DOI: 10.1101/2023.08.26.554851

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