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Aβ and tau prions feature in the neuropathogenesis of Down syndrome

7 Nov 2022

Abstract excerpt

Down syndrome (DS) is caused by the triplication of chromosome 21 and is the most common chromosomal disorder in humans. Those individuals with DS who live beyond age 40 y develop a progressive dementia that is similar to Alzheimer's disease (AD). Both DS and AD brains exhibit numerous extracellular amyloid plaques composed of Aβ and intracellular neurofibrillary tangles composed of tau. Since AD is a...

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PMID: 36343257
DOI: 10.1073/pnas.2212954119

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