Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aβ propagation and strains: Implications for the phenotypic diversity in Alzheimer's disease.

Neurobiology of disease - 1 Jan 2018

Condello Carlo, Stöehr Jan

Abstract excerpt

The progressive nature of Alzheimer's disease (AD) is thought to occur, at least in part, by the self-replication and spreading of Aβ and Tau aggregates through a prion mechanism. Evidence now exists that structural variants of Aβ prions can propagate their distinct conformations through template-directed folding of naïve Aβ peptides. This notion implicates that the first self-propagating Aβ assembly to emerge in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Alzheimer's disease research and treatments
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Prion Diseases and Protein Misfolding

Share to Protein Conformation

Share to Protein Structure and Dynamics

Source

Identifiers

PMID: 28359847
DOI: 10.1016/j.nbd.2017.03.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aβ propagation and strains: Implications for the phenotypic diversity in Alzheimer's disease.PMID 28359847Read ↗

The existence of Aβ strains and their potential for driving phenotypic heterogeneity in Alzheimer's disease.Semantic proximity Read ↗

Distinct prion-like strains of amyloid beta implicated in phenotypic diversity of Alzheimer's disease.Semantic proximity Read ↗

Populations of Tau Conformers Drive Prion-like Strain Effects in Alzheimer’s Disease and Related DementiasSemantic proximity Read ↗

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes.Semantic proximity Read ↗

Serial propagation of distinct strains of Aβ prions from Alzheimer’s disease patientsSemantic proximity Read ↗

Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer’s disease pathology in Down syndromeSemantic proximity Read ↗

Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s diseaseSemantic proximity Read ↗

Molecular foundations of prion strain diversity.Semantic proximity Read ↗

Emergence of distinct and heterogeneous strains of amyloid beta as Alzheimer’s disease progresses in Down syndromeSemantic proximity Read ↗

Prion and Prion-Like Protein Strains: Deciphering the Molecular Basis of Heterogeneity in NeurodegenerationSemantic proximity Read ↗

Proteopathic Strains and the Heterogeneity of Neurodegenerative DiseasesSemantic proximity Read ↗

One or more β-amyloid(s)? New insights into the prion-like nature of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.