Article

Histone H3S28 Phosphorylation Promotes a Senescence-Associated Survival Program Following PARP Inhibition in Hormone Receptor-Positive Breast Cancer

2026-08-06

Abstract excerpt

<title>Abstract</title> Background: PARP1 inhibitors (PARPi) are a key therapeutic strategy in BRCA1/2-mutated and increasingly in homologous recombination (HR)-positive breast cancers. However, resistance and relapse remain major challenges. While most studies focus on DNA repair restoration, chromatin-based mechanisms of PARPi response are less understood. PARP1 regulates DNA repair and chromatin organisat...

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Literature Corpus work: b9adbfaf-2469-5874-8936-58f73e6b7b6b
DOI: 10.21203/rs.3.rs-10431382/v1

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