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Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

11 Jun 2019

Abstract excerpt

Senescence is a tumor suppression mechanism defined by stable proliferation arrest. Here we demonstrate that the known synthetic lethal interaction between poly(ADP-ribose) polymerase 1 inhibitors (PARPi) and DNA repair triggers p53-independent ovarian cancer cell senescence defined by senescence-associated phenotypic hallmarks including DNA-SCARS, inflammatory secretome, Bcl-XL-mediated apoptosis resistance, and...

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PMID: 31186408
DOI: 10.1038/s41467-019-10460-1

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