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Tumor Cell Recovery from Senescence Induced by Radiation with PARP Inhibition

2 Sept 2016

Abstract excerpt

Inhibitors of poly(ADP-ribose) polymerase (PARP) are clinically used as single-agent therapy for tumors with BRCA1 or BRCA2 mutations. One approach to expanding the use of PARP inhibitors to a wider range of tumors is to combine them with cytotoxic chemotherapy or radiotherapy. Preclinical studies in experimental animals and tumor cells in culture indicate that PARP inhibition modestly sensitizes most tumor cells...

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PMID: 27588595
DOI: 10.1667/rr14437.1

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