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Article

Microglia Attenuate Neuroinflammation After Subarachnoid Hemorrhage by Modulating Astrocyte Phenotypic Transformation via the RARα/Mafb/Msr1 Pathway.

Molecular neurobiology - 5 Jun 2026

Meng Yuxiao, Dong Yuanzhe, Shao Jiang, Wu Qiaowei, Huang Le, Wu Pei, Lan Shuai, Yao Zurong, Shi Huaizhang, Li Yuchen

Abstract excerpt

Neuroinflammation mediated by microglia-astrocyte interactions significantly contributes to secondary brain injury after subarachnoid hemorrhage (SAH). Retinoic acid receptor alpha (RARα) has emerged as a potential modulator of neuroinflammation. However, its specific mechanisms in the interaction between microglia and astrocytes after SAH are not yet known. This study investigated whether RARα activation might...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42243462
DOI: 10.1007/s12035-026-05965-y
PMCID: PMC13236732

Genes

IL6R
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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