Article

Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation

2002-04-15

Abstract excerpt

LMX1B encodes a LIM-homeodomain transcription factor. Mutations in LMX1B cause nail-patella syndrome (NPS), an autosomal dominant disease with skeletal abnormalities, nail hypoplasia, and nephropathy. Expression of glomerular basement membrane (GBM) collagens is reduced in Lmx1b–/– mice, suggesting one basis for NPS nephropathy. Here, we show that Lmx1b–/– podocytes have reduced numbers of foot processes, are dysp...

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Literature Corpus work: b94b92a8-df85-560d-afe0-49e5b8790f3b
DOI: 10.1172/jci0213954

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