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Article

LMX1B is Essential for the Maintenance of Differentiated Podocytes in Adult Kidneys

30 Aug 2013

Abstract excerpt

Mutations of the LMX1B gene cause nail-patella syndrome, a rare autosomal-dominant disorder affecting the development of the limbs, eyes, brain, and kidneys. The characterization of conventional Lmx1b knockout mice has shown that LMX1B regulates the development of podocyte foot processes and slit diaphragms, but studies using podocyte-specific Lmx1b knockout mice have yielded conflicting results regarding the...

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Identifiers

PMID: 23990680
DOI: 10.1681/asn.2012080788

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Related research

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Research trail→

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LMX1B is Essential for the Maintenance of Differentiated Podocytes in Adult KidneysPMID 23990680Read ↗

Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiationSemantic proximity Read ↗

Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiationSemantic proximity Read ↗

The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes.Semantic proximity Read ↗

The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytesSemantic proximity Read ↗

The signaling pathways of LMX1B and its role in glomerulosclerosisSemantic proximity Read ↗

Nail-patella syndrome.Semantic proximity Read ↗

Clinical and histological findings of autosomal dominant renal-limited disease with LMX1B mutation.Semantic proximity Read ↗

The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytesSemantic proximity Read ↗

Identification of limb-specific Lmx1b auto-regulatory modules with Nail-patella syndrome pathogenicity.Semantic proximity Read ↗

Kidney disease in nail-patella syndrome.Semantic proximity Read ↗

Characterisation of lmx1b paralogues in zebrafish reveals divergent roles in skeletal, kidney, and muscle developmentSemantic proximity Read ↗

Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome.Semantic proximity Read ↗

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