Article
The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes.
The Journal of clinical investigation - 1 Apr 2002
Rohr Claudia, Prestel Jürgen, Heidet Laurence, Hosser Hiltraud, Kriz Wilhelm, Johnson Randy L, Antignac Corinne, Witzgall Ralph
Abstract excerpt
Patients with nail-patella syndrome often suffer from a nephropathy, which ultimately results in chronic renal failure. The finding that this disease is caused by mutations in the transcription factor LMX1B, which in the kidney is expressed exclusively in podocytes, offers the opportunity for a better understanding of the renal pathogenesis. In our analysis of the nephropathy in nail-patella syndrome, we have...
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