Article

The unfolded protein response triggers the immune deficiency pathway in ticks

2021-09-01

Abstract excerpt

<h4>ABSTRACT</h4> The insect immune deficiency (IMD) pathway is a defense mechanism that senses and responds to Gram negative bacteria. Ticks lack genes encoding upstream components that initiate the IMD pathway. Despite this deficiency, core signaling molecules are present and functionally restrict tick-borne pathogens. The molecular events preceding activation remain undefined. Here, we show that the Unfolded P...

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Literature Corpus work: b940eaf3-85be-5e56-be81-9be76817e288
DOI: 10.1101/2021.08.31.458430

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