Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATF6 enables pathogen infection in ticks by inducing stomatin and altering cholesterol dynamics

17 Jun 2025

Abstract excerpt

How tick-borne pathogens interact with their hosts has been primarily studied in vertebrates where disease is observed. Comparatively less is known about pathogen interactions within the tick. Here, we report that Ixodes scapularis ticks infected with either Anaplasma phagocytophilum (causative agent of anaplasmosis) or Borrelia burgdorferi (causative agent of Lyme disease) show activation of the ATF6 branch of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to Vector-borne infectious diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40526719
DOI: 10.1073/pnas.2501045122

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATF6 enables pathogen infection in ticks by inducing stomatin and altering cholesterol dynamicsPMID 40526719Read ↗

ATF6 enables pathogen infection in ticks by inducing <i>stomatin</i> and altering cholesterol dynamicsSemantic proximity Read ↗

PERK-mediated antioxidant response is key for pathogen persistence in ticksSemantic proximity Read ↗

The unfolded protein response triggers the immune deficiency pathway in ticksSemantic proximity Read ↗

The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency PathwaySemantic proximity Read ↗

Tick extracellular vesicles alter keratinocyte function in the skin epidermisSemantic proximity Read ↗

IrSPI, a Tick Serine Protease Inhibitor Involved in Tick Feeding and Bartonella henselae InfectionSemantic proximity Read ↗

De novo assembly and analysis of midgut transcriptome of the argasid tick Ornithodoros erraticus and identification of genes differentially expressed after blood feedingSemantic proximity Read ↗

Borrelia burgdorferi bbk13 Is Critical for Spirochete Population Expansion in the Skin during Early InfectionSemantic proximity Read ↗

CD36 homologs determine microbial resistance to the Lyme disease spirocheteSemantic proximity Read ↗

Insights into tick-pathogen interactions – a single cell RNA sequencing approach of transcriptional changes during ehrlichial infectionSemantic proximity Read ↗

Arthropods Under Pressure: Stress Responses and Immunity at the Pathogen-Vector InterfaceSemantic proximity Read ↗

Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmissionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.