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Article

Infection-derived lipids elicit an immune deficiency circuit in arthropods

14 Feb 2017

Abstract excerpt

The insect immune deficiency (IMD) pathway resembles the tumour necrosis factor receptor network in mammals and senses diaminopimelic-type peptidoglycans present in Gram-negative bacteria. Whether unidentified chemical moieties activate the IMD signalling cascade remains unknown. Here, we show that infection-derived lipids 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG) and 1-palmitoyl-2-oleoyl...

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PMID: 28195158
DOI: 10.1038/ncomms14401

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