p47 licenses activation of the immune deficiency pathway in the tick Ixodes scapularis

Abstract excerpt

Significance Translocation of the nuclear factor (NF)-κB homolog Relish in response to microbial infection is a hallmark of the arthropod immune deficiency (IMD) pathway. Classically, transduction within the IMD molecular cascade is regulated by the inhibitor of apoptosis protein 2 (IAP2). In the Lyme disease Ixodes scapularis tick, X-linked inhibitor of apoptosis (XIAP) is considered a functionally analogous...

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