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Article

A synergistic interaction between HDAC‐ and PARP inhibitors in childhood tumors with chromothripsis

12 Apr 2022

Abstract excerpt

Chromothripsis is a form of genomic instability characterized by the occurrence of tens to hundreds of clustered DNA double-strand breaks in a one-off catastrophic event. Rearrangements associated with chromothripsis are detectable in numerous tumor entities and linked with poor prognosis in some of these, such as Sonic Hedgehog medulloblastoma, neuroblastoma and osteosarcoma. Hence, there is a need for...

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PMID: 35411591
DOI: 10.1002/ijc.34027

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