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Through a glass, darkly? HepaRG and HepG2 cells as models of human phase I drug metabolism

2 Jan 2022

Abstract excerpt

models of hepatic metabolism and toxicity. Predominant among these is the HepG2 cell line, although HepaRG is becoming increasingly popular because of its perceived closer resemblance to human hepatocytes. We review the functionality of these cell lines in terms of Phase I protein expression, basal cytochrome P450-dependent activity, and utility in P450 induction studies. Our analysis indicates that HepG2 cells...

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PMID: 35188018
DOI: 10.1080/03602532.2022.2039688

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