Article

A Soluble ACE2 Microbody Protein Fused to a Single Immunoglobulin Fc Domain is a Potent Inhibitor of SARS-CoV-2 Infection

2020-09-21

Abstract excerpt

Soluble forms of ACE2 have recently been shown to inhibit SARS-CoV-2 infection. We report on an improved soluble ACE2, termed a “microbody” in which the ACE2 ectodomain is fused to Fc domain 3 of the immunoglobulin heavy chain. The protein is smaller than previously described ACE2-Ig Fc fusion proteins and contains an H345A mutation in the ACE2 catalytic active site that inactivates the enzyme without reducing its...

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Literature Corpus work: 6e8b3453-4b48-5f9b-8e90-cdd66844a6c5
DOI: 10.2139/ssrn.3677223

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