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DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages

26 Oct 2023

Abstract excerpt

Malaria-associated pathogenesis such as parasite invasion, egress, host cell remodelling and antigenic variation requires concerted action by many proteins, but the molecular regulation is poorly understood. Here we have characterized an essential Plasmodium-specific Apicomplexan AP2 transcription factor in Plasmodium falciparum (PfAP2-P; pathogenesis) during the blood-stage development with two peaks of...

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PMID: 37884813
DOI: 10.1038/s41564-023-01497-6

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