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Article

A baseline transcriptional signature associates with clinical malaria risk in RTS,S/AS01-vaccinated African children

2021-05-19

Abstract excerpt

In a phase 3 trial in African infants/children, the RTS,S/AS01 (GSK) vaccine showed moderate efficacy against clinical malaria. We aimed to identify RTS,S/AS01-induced signatures associated with clinical malaria by analyzing antigen-stimulated peripheral blood mononuclear cells sampled from a subset of trial participants at baseline and month 3 (one month post-third dose). RTS,S/AS01 vaccination was associated wit...

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Identifiers and source

Literature Corpus work
0a659a7c-2d69-55ea-8927-4a85cb42b8c9
DOI
10.1101/2021.05.19.21257227
Open publication

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A baseline transcriptional signature associates with clinical malaria risk in RTS,S/AS01-vaccinated African childrenDOI 10.1101/2021.05.19.21257227
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