Article

Di- and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair

2023-10-19

Abstract excerpt

Histone H3 Lys36 (H3K36) methylation and its associated modifiers are crucial for DNA double-strand break (DSB) repair, but the mechanism governing whether and how different H3K36 methylation forms impact repair pathways is unclear. Here, we unveil the distinct roles of H3K36 dimethylation (H3K36me2) and H3K36 trimethylation (H3K36me3) in DSB repair via non-homologous end joining (NHEJ) or homologous recombination...

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Literature Corpus work: b779a135-4b9f-541e-a5a0-14d7e613d76a
DOI: 10.1101/2023.10.18.562911

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