Article

Generation of nanobodies targeting the human, transcobalamin-mediated vitamin B <sub>12</sub> uptake route

2021-08-16

Abstract excerpt

Cellular uptake of vitamin B 12 in humans is mediated by the endocytosis of the B 12 carrier protein transcobalamin (TC) via its cognate cell surface receptor TCblR (or CD320), encoded by the CD320 gene(1). Because CD320 expression is associated with the cell cycle and upregulated in highly proliferating cells such as cancer cells(2–4), this uptake route is a potential target for cancer therapy(5). We develope...

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Literature Corpus work: b756a0cb-5907-5923-847d-e284d64a76a6
DOI: 10.1101/2021.08.16.456495

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