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Article

Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome

10 Jan 2019

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 30639036
DOI: 10.1016/j.stem.2018.12.003

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Related research

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Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX SyndromePMID 30639036Read ↗

CD4⁺ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer.Semantic proximity Read ↗

Towards gene therapy for IPEX syndrome.Semantic proximity Read ↗

From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation.Semantic proximity Read ↗

CRISPR-based gene editing enables FOXP3 gene repair in IPEX patient cells.Semantic proximity Read ↗

IPEX due to an exon 7 skipping FOXP3 mutation with autoimmune diabetes mellitus cured by selective TReg cell engraftment.Semantic proximity Read ↗

Reduced FOXP3 expression causes IPEX syndrome onset: An implication from an IPEX patient and his disease-free twin brother.Semantic proximity Read ↗

IPEX and FOXP3: clinical and research perspectives.Semantic proximity Read ↗

Genetic control of the inflammatory T-cell response in regulatory T-cell deficient scurfy mice.Semantic proximity Read ↗

Foxp3: a genetic foundation for regulatory T cell differentiation and function.Semantic proximity Read ↗

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.Semantic proximity Read ↗

Co-Expression of FOXP3FL and FOXP3Δ2 Isoforms Is Required for Optimal Treg-Like Cell Phenotypes and Suppressive Function.Semantic proximity Read ↗

IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomena.Semantic proximity Read ↗

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