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Article

Regulatory T cells, derived from naïve CD4+CD25- T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance.

Transplantation - 27 May 2005

Chai Jian-Guo, Xue Shao-An, Coe David, Addey Caroline, Bartok Istvan, Scott Diane, Simpson Elizabeth, Stauss Hans J, Hori Shohei, Sakaguchi Shimon, Dyson Julian

Abstract excerpt

BACKGROUND: Regulatory T (Treg) cells, generated in vitro by Foxp3 gene transfer into naive CD4+25- T cells, have been shown to inhibit the development of inflammation and autoimmune disease, but it is not known whether they are able to prevent allograft rejection. This study investigated whether...

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Source

Identifiers

PMID: 15912097
DOI: 10.1097/01.tp.0000159147.56408.9c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15912097-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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