Article

Lipid Transfer Proteins and PI4KIIα Initiate Nuclear p53-Phosphoinositide Signaling

2023-05-09

Abstract excerpt

<h4>Summary</h4> Phosphoinositide (PIP n ) messengers are present in non-membranous regions of nuclei where they are assembled into a phosphatidylinositol (PI) 3-kinase (PI3K)/Akt pathway that is distinct from the cytosolic membrane-localized pathway. In the nuclear pathway, PI kinases/phosphatases bind the p53 tumor suppressor protein (wild-type and mutant) to generate p53-PIP n complexes (p53-PIP n signaloso...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b6d05ba1-4f94-56ef-9d00-dba05e8d310c
DOI: 10.1101/2023.05.08.539894

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lipid Transfer Proteins and PI4KIIα Initiate Nuclear p53-Phosphoinositide SignalingDOI 10.1101/2023.05.08.539894Read

Expanding role of PI5P4Ks in cancer: A promising druggable targetSemantic proximity Read

The nuclear phosphoinositide-p53 signalosome in the regulation of cell motilitySemantic proximity Read

Nuclear PI3K signaling in cell growth and tumorigenesisSemantic proximity Read

Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate.Semantic proximity Read

Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation.Semantic proximity Read

Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding.Semantic proximity Read

An immunochemical analysis of the human nuclear phosphoprotein p53Semantic proximity Read

Nuclear phosphoinositides and their roles in cell biology and diseaseSemantic proximity Read

Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulationSemantic proximity Read

TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interactionSemantic proximity Read

Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1Semantic proximity Read

Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.Semantic proximity Read