Article
Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding.
Molecular cell - 21 Dec 2017
Liao Peng, Zeng Shelya X, Zhou Xiang, Chen Tianjian, Zhou Fen, Cao Bo, Jung Ji Hoon, Del Sal Giannino, Luo Shiwen, Lu Hua
Abstract excerpt
TP53 missense mutations significantly influence the development and progression of various human cancers via their gain of new functions (GOF) through different mechanisms. Here we report a unique mechanism underlying the GOF of p53-R249S (p53-RS), a p53 mutant frequently detected in human hepatocellular carcinoma (HCC) that is highly related to hepatitis B infection and aflatoxin B1. A CDK inhibitor blocks...
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